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Quantification of Sox2+ SCs and Myosin7a+ HCs. HC, hair cell; SC, supporting cell.

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posted on 2021-11-10, 18:31 authored by Tomokatsu Udagawa, Patrick J. Atkinson, Beatrice Milon, Julia M. Abitbol, Yang Song, Michal Sperber, Elvis Huarcaya Najarro, Mirko Scheibinger, Ran Elkon, Ronna Hertzano, Alan G. Cheng

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Lineage-tracing and translatomic analysis of damage-inducible mitotic cochlear progenitors identifies candidate genes regulating regeneration
PLOS BiologyPLOS Biology

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sup >+</ supgreater epithelial ridgegene clustering algorithmslike cells criticalcochlear supporting cellsnonmitotically regenerate scsdiv >< pfound mitotic regenerationreplenish ablated scsmitotic regenerationmitotic progenitorsger cellsscs usingvia ribotagtranslatomic analysisrobustly divideregenerative potentialneonatal cochleamature cochleahearing functiondtr </ablated lgr5

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