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PyBidine–NiCl2‑Catalyzed Asymmetric Addition of Alcohols and Peroxides to Isatin-Derived Ketimines

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posted on 15.05.2015, 00:00 by Takayoshi Arai, Kento Tsuchiya, Eri Matsumura
An (S,S)-diphenyldiamine-derived bis­(imidazolidine)­pyridine (PyBidine)–NiCl2 complex catalyzed the asymmetric addition of methanol and peroxides to isatin-derived N-Boc-imines to form chiral quaternary N,O-acetals at the C3 position of the resulting oxiindoles in up to 99% yield with 94% ee.