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Proteins identified from pull down experiments of WT, PKG_GFP, PKG_T695A and PKG_T695E.

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posted on 2024-06-27, 18:11 authored by Konstantinos Koussis, Silvia Haase, Chrislaine Withers-Martinez, Helen R. Flynn, Simone Kunzelmann, Evangelos Christodoulou, Fairouz Ibrahim, Mark Skehel, David A. Baker, Michael J. Blackman

Proteins identified from pull down experiments of WT, PKG_GFP, PKG_T695A and PKG_T695E.

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    PLOS Pathogens

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    transduce signals crucialremain poorly understoodkey threonine residueprevents parasite egressparasite life cycledependent protein kinasesole cgmp sensorreduced cgmp bindingpkg regulate egressmalarial pkg regulationessential signalling hubdiv >< pt695 phosphorylation leadingactivation loop phosphorylationactivation loopparasite proteomekinase activitypkg functioncgmp saturationvivo vitro use geneticuniquely regulatedsubstrate specificityplasmodium many aspectsmalaria parasitesfindings indicatebiochemical approaches

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