This file contains single-cell RNA-seq datasets associated with :
Chen, S, et al. 2020. “Dissecting Heterogeneous Cell Populations across Drug and Disease Conditions with PopAlign.” bioRxiv. https://doi.org/10.1101/421354.
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DATASETS
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Each data folder includes:
barcodes.tsv : cell barcodes
genes.tsv : genes
[ Name ].mtx : sparse matrix file of transcript counts
Subfolders
MM1-MM4:
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22,294 Peripheral Blood Mononuclear Cells (PBMCs) from four multiple myeloma patients.
Data collected using 10x 3' Gene Expression v2 kit.
healthy1/healthy2:
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12,865 PBMCs from two healthy donors.
Data collected using 10x 3' Gene Expression v2 kit.
drugscreen:
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33,482 cells
40 drugs applied at 1uM for 24 hours onto PBMCs collected from a single healthy donor.
Data collected using 10x 3' Gene Expression v3 kit.
Includes a metadata file (meta.csv) with each row corresponding to each cell in the gene expression matrix.