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PharmacotherapyDB 1.0: the open catalog of drug therapies for disease
dataset
posted on 2016-03-15, 20:07 authored by Daniel HimmelsteinDaniel Himmelstein, Pouya Khankhanian, Christine S. Hessler, Ari J. Green, Sergio BaranziniSergio BaranziniThis is the initial release of the PharmacotherapyDB, a catalog of drug therapies for disease. The catalog contains physician curated medical indications.
This release contains 97 diseases and 601 drugs. Between these drug–disease pairs, there are 755 disease-modifying therapies, 390 symptomatic therapies, and 243 non-indications. To enable integrative analyses, drugs and diseases are coded using DrugBank and Disease Ontology identifiers.
Indications were classified by physician curators into three categories:
DM
-- disease modifyingSYM
-- symptomaticNOT
-- non-indication
This deposition contains the following files:
indications.tsv
contains drug–disease pairs and their consensus category (DM
,SYM
, orNOT
).n_curators
refers to how many of the three curators initially assigned the consensus classification.n_resources
refers to how many of the four resources (MEDI-HPS, LabeledIn, EHRLink, PREDICT) included the indication.diseases.tsv
contains a list of diseases with indications. For each disease, the number of indications per category is provided.drugs.tsv
contains a list of drugs with indications. For each drug, the number of indications per category is provided.catalog.xlsx
is a spreadsheet with four sheets:indications
— data fromindications.tsv
diseases
— data fromdiseases.tsv
drugs
— data fromdrugs.tsv
curation
— the classifications from each of the three physician curators (AJG
,CSH
, &PK
).
The catalog is released as CC0 1.0. However, please consider that the catalog includes DrugBank and DIsease Ontology identifiers and reference their licenses when appropriate.