Pharmacokinetic parameter estimates.
Datasets usually provide raw data for analysis. This raw data often comes in spreadsheet form, but can be any collection of data, on which analysis can be performed.
The table displays the estimated pharmacokinetic parameter estimates for healthy individuals. Interindiviual variability (random effects) was included on drug clearance CL/Fbio and the volume of distribution Vc/Fbio. These parameters were log-normal distributed as outlined in the Methods section, eq (11), with coefficient of variation [%] , where σ2 is the variance of the associated normal distribution. A covariance of between x = CL/Fbio and y = Vc/Fbio was estimated. The absorption rate constant was fixed  to 2.24h−1. Residual variability (eq (10)) was described by a combined proportional-additive model for healthy volunteers [σ = 0.213 (37.2%) and 0.0019 mg/L (40.9%), respectively] and a proportional error model for HIV-infected patients [σ = 0.402 (24.2%)].