ol7b00784_si_003.cif (774.2 kB)

Palladium(0)-Catalyzed Dearomative [3 + 2] Cycloaddition of 3‑Nitroindoles with Vinylcyclopropanes: An Entry to Stereodefined 2,3-Fused Cyclopentannulated Indoline Derivatives

Download (774.2 kB)
posted on 2017-04-18, 15:06 authored by Maxime Laugeois, Johanne Ling, Charlène Férard, Véronique Michelet, Virginie Ratovelomanana-Vidal, Maxime R. Vitale
The palladium(0)-catalyzed diastereoselective dearomative cyclopentannulation of 3-nitroindoles with vinylcyclopropanes is described. This straightforward and highly atom-economical method leads to a wide range of functionalized indolines in good yields and diastereoselectivities and represents an unprecedented entry toward the valuable 2,3-fused cyclopentannulated indoline scaffold.