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Pairwise differential accessibility analysis for MTX vs VEH at 3 hours.

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posted on 2025-10-14, 17:45 authored by E. Renee Matthews, Raodatullah O. Abodunrin, John D. Hurley, Sayan Paul, José A. Gutiérrez, Alyssa R. Bogar, Michelle C. Ward
<p>Pairwise differential accessibility analysis for MTX vs VEH at 3 hours.</p>

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    PLOS Genetics

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    results demonstrate largefour healthy individualscancer patient populationsderived cardiomyocytes derivedcardiomyocyte chromatin accessibilityincreased histone acetylationcvd risk lociopen chromatin regionstop2 inhibitor treatmentsdiv >< pincreased chromatin accessibilityresponsive chromatin regionshf risk locichromatin accessibilityresponsive regionsregions boundcoding regionsrisk estimationultimately affecttopoisomerase iitop2 betasnp associatesregulatory potentialmismatch repairidentified tensidentified druggenetic variantsdrugs affectdifferentially accessiblecdkn1a </cardiovascular diseasescardiomyocytes treatedbound regionatrial fibrillationannotate variants24 hours14 hf

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