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secondary-screen-replicate-collapsed-logfold-change.csv (87.38 MB)
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secondary-screen-replicate-treatment-info.csv (14.96 MB)
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PRISM Repurposing 19Q4 Dataset

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Version 4 2019-12-17, 21:34
Version 3 2019-11-07, 20:47
Version 2 2019-09-19, 19:50
Version 1 2019-08-09, 17:17
dataset
posted on 2019-12-17, 21:34 authored by Broad DepMapBroad DepMap, Steven Corsello, Mustafa Kocak, Todd Golub

The PRISM Repurposing release contains small molecule viability datasets generated using the Broad Repurposing Library and the PRISM multiplexed cell-line viability assay.


The primary PRISM Repurposing dataset contains the results of pooled-cell line chemical-perturbation viability screens for 4,518 compounds screened against 578 or 562 cell lines.


The secondary PRISM Repurposing dataset contains the results of pooled-cell line chemical-perturbation viability screens for 1,448 compounds screened against 489 cell lines in an 8-step, 4-fold dilution, starting from 10uM. Technical redos for 147 previously screened oncology compounds have been added as of 11/22/2019. This data is identified using a `screen_id` of "MTS010". It is recommended to use MTS010 when available. MTS010 was not included in the analysis for Corsello et al. 2019, DOI:10.1101/730119.


Data processing steps are described in the README files. Further descriptions of methods are available at https://doi.org/10.1101/730119.


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    Keywords

    PRISMCancer genomicsDrug screeningBiomarker discoveryDrug repurposingCancer Cell BiologyCancer Therapy (excl. Chemotherapy and Radiation Therapy)CancerPharmacogenomics

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    CC BY 4.0

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