posted on 17.12.2019, 21:34by Broad DepMap, Steven Corsello, Mustafa Kocak, Todd Golub
The PRISM Repurposing release contains small molecule viability datasets generated using the Broad Repurposing Library and the PRISM multiplexed cell-line viability assay.
The primary PRISM Repurposing dataset contains the results of pooled-cell line chemical-perturbation viability screens for 4,518 compounds screened against 578 or 562 cell lines.
The secondary PRISM Repurposing dataset contains the results of pooled-cell line chemical-perturbation viability screens for 1,448 compounds screened against 489 cell lines in an 8-step, 4-fold dilution, starting from 10uM. Technical redos for 147 previously screened oncology compounds have been added as of 11/22/2019. This data is identified using a `screen_id` of "MTS010". It is recommended to use MTS010 when available. MTS010 was not included in the analysis for Corsello et al. 2019, DOI:10.1101/730119.
Data processing steps are described in the README files. Further descriptions of methods are available at https://doi.org/10.1101/730119.