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Oxidation Reactivity Channels for 2-(Pyridin-2-yl)-N,N-diphenylacetamides

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posted on 23.11.2007, 00:00 by Sylvie Pailloux, Iris Binyamin, Lorraine M. Deck, Brian M. Rapko, Benjamin P. Hay, Eileen N. Duesler, Robert T. Paine
Synthetic routes to 2-(pyridin-2-yl)-N,N-diphenylacetamide and 2-(6-methylpyridin-2-yl)-N,N-diphenyl-acetamide are described along with results from the chemical oxidation of these compounds with peracetic acid, m-chloroperbenzoic acid, and OXONE. In each case, oxidations generate four products in varying amounts depending on the oxidant and reaction conditions. Each product has been characterized by spectroscopic methods and the molecular structures of several of the new compounds have been confirmed by X-ray crystallography.