pgen.1010109.s010.xlsx (32.38 kB)
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posted on 2022-03-14, 17:42 authored by Anne Sophie Reuter, David Stern, Alice Bernard, Chiara Goossens, Arnaud Lavergne, Lydie Flasse, Virginie Von Berg, Isabelle Manfroid, Bernard Peers, Marianne L. Voz(XLSX)
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yet fully understoodspecific subtype identitiessecretory regulatory cascadegeneric cell fatesdisplay specific activitiescell fate specificationgoblet cell differentiationdistinct secretory cellsphenotype also observedintestinal secretory lineage>-/- mutant embryosgoblet cells concomitantgoblet cells anymoreascl1a protein reversesascl1a chimeric proteinuce ), presentoverexpressed different arpevolutionarily conserved domaindiv >< pascl transcription factorsgoblet cellsenteroendocrine cellsuce domainnull mutantenteroendocrine lineageconserved elementalso expressedascl proteinsascl factorsascl1a </wide varietysimilar rolerescuing capacityrepress gfi1neurod memberskey determinantsgfi1aa </gfi1 actsfunctional divergencefunction experimentsfirst stepcrucial functionaa ultra
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