Mutations in the TLD-resistant evolved isolate in the MDS42 background.
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posted on 2022-10-24, 17:31 authored by Alexandra Ketcham, Peter L. Freddolino, Saeed Tavazoie<p>Mutations in the TLD-resistant evolved isolate in the MDS42 background.</p>
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underlying killing mechanismpreviously unknown rolepreviously implicated pathwaysdiv >< pdiscovering novel genesrobust early eventenigmatic process knowncommon mechanistic stepescherichia coli </intracellular acidification maycoli </mechanistic understandingdeath processcausal eventintracellular phintracellular acidificatione </unbiased approachesthymineless deathsystematically determinestudies revealedstill lackregulatory underpinningsdiverse setdiverse antimicrobialdespite decadescytoplasmic phcausal sequencebactericidal effectsantineoplastic drugsantibiotic gentamicinalso observe
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