This study explored the knowledge, attitudes, and perceptions of contraception, HIV, and PrEP of adolescent girls and young women (AGYW, aged 15-24) in Mozambique. Between May-June 2022, a cross-sectional survey was done among a convenience sample of AGYW receiving healthcare in Nampula, Mozambique. Information on demographics, sexual behavior, contraception knowledge, HIV testing experience, HIV knowledge, PrEP knowledge and attitudes, PrEP stigma, and PrEP modality preference and service delivery was collected.