ja511757j_si_002.cif (37.06 kB)
Modeling TauD‑J: A High-Spin Nonheme Oxoiron(IV) Complex with High Reactivity toward C–H Bonds
dataset
posted on 2015-02-25, 00:00 authored by Achintesh
N. Biswas, Mayank Puri, Katlyn K. Meier, Williamson N. Oloo, Gregory T. Rohde, Emile L. Bominaar, Eckard Münck, Lawrence QueHigh-spin oxoiron(IV) species are
often implicated in the mechanisms
of nonheme iron oxygenases, their C–H bond cleaving properties
being attributed to the quintet spin state. However, the few available
synthetic S = 2 FeIVO complexes
supported by polydentate ligands do not cleave strong C–H bonds.
Herein we report the characterization of a highly reactive S = 2 complex, [FeIV(O)(TQA)(NCMe)]2+ (2) (TQA = tris(2-quinolylmethyl)amine), which oxidizes
both C–H and CC bonds at −40 °C. The oxidation
of cyclohexane by 2 occurs at a rate comparable to that
of the oxidation of taurine by the TauD-J enzyme intermediate after adjustment for the different temperatures
of measurement. Moreover, compared with other S =
2 complexes characterized to date, the spectroscopic properties of 2 most closely resemble those of TauD-J. Together these features make 2 the best electronic and functional model for TauD-J to date.
