pone.0278295.s002.xlsx (9.77 MB)
Download fileList of differentially expressed genes at all time points.
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posted on 2022-12-01, 18:50 authored by Stuart Meier, James A. Seddon, Elizna Maasdorp, Léanie Kleynhans, Nelita du Plessis, Andre G. Loxton, Stephanus T. Malherbe, Daniel E. Zak, Ethan Thompson, Fergal J. Duffy, Stefan H. E. Kaufmann, Tom H. M. Ottenhoff, Thomas J. Scriba, Sara Suliman, Jayne S. Sutherland, Jill Winter, Helena Kuivaniemi, Gerhard Walzl, Gerard TrompThe statistical metrics presented for each comparison include: log2 fold change (log2FC), average log2 counts per million (logCPM), quasi-likelihood F-statistic (F), p-value (PValue) and false discovery rate (FDR). The non-TB time zero baseline group from the GC6 study were the control group for all comparisons prior to TB diagnosis (i.e., 24, 18, 12 and 6 months before diagnosis) while the Catalysis study healthy controls served as the baseline for the TB comparison.
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specific effector mechanismshost immune responses74 study ).severe lung diseasepositron emission tomography>) causes tuberculosistime points closermycobacterium tuberculosis </comparing tb patients90 tb patientslung damage comparedlung damagetime pointstb patientsleading causescomputed tomographytb pathogenesistb controlstb </whole bloodsteady increasesix monthsscan resultsresults revealedremains oneprovide detailspotent activationplatelets playplatelet degranulationnet formationmortality duemay contributelarge overlapinfectious pathogenindividuals spanningindependent cohortfour sixfindings suggestearly stagesdifferentially expressedcritical rolealso enriched86 %)
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