Invasiveness estimates for serotypes and strains, calculated from genotyped isolates from child disease and carriage.
dataset
posted on 2022-02-17, 18:49 authored by Alessandra Løchen, James E. Truscott, Nicholas J. CroucherEach row corresponds to a serotype-strain combination. Both the invasiveness associated with the serotype, and the invasiveness coefficient associated with the strain, are listed, along with the corresponding lower and upper bounds of their 95% credibility intervals.
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public health interventionsproblematic following vaccineheterogeneous geographical distributionhence genomic surveillancefound significant evidenceaccurately reproduced observationsrstan package (<disease burden attributablecause symptomatic diseasebayesian models producedsmaller sample sizesidentified historically rareenabling ongoing metadiv >< pstreptococcus pneumoniae opportunistic pathogens dependssample sizespneumoniae package allowsopportunistic pathogensmodels convergedinvasive diseasedisease casestyped microbestherefore likelystable fitsserotype variationserotype informationodds ratiosmodel comparisonsinfections causedidentify newhypothesis testinghealthy carriersdimensionless valuesbayes factorsbacterial populationasymptomatic colonisationassociated disruption
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