Intestinal cGAS-STING-IFN Signaling Promotes Obesity by Downregulating Microbiota-Derived IAA in Male Mice

<p dir="ltr">The gut constantly interacts to both pathogens and dietary signals, but how it balances immune and metabolic responses remains unclear. Here, we identify intestinal cGAS, a key DNA sensor, as a central regulator linking gut immunity to whole-body metabolism.</p>