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Indole Alkaloids with New Skeleton Activating Neural Stem Cells

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posted on 07.11.2014 by Xing-Wei Yang, Cui-Ping Yang, Li-Ping Jiang, Xu-Jie Qin, Ya-Ping Liu, Qiu-Shuo Shen, Yong-Bin Chen, Xiao-Dong Luo
Alstoscholarisines A–E (15), five unprecedented monoterpenoid indole alkaloids with 6/5/6/6/6 fused-bridge rings, were isolated from Alstonia scholaris. They promoted adult neuronal stem cells (NSCs) proliferation significantly, in which the most active one (1) functioned from a concentration of 0.1 μg/mL in a dosage-dependent manner. Furthermore, 1 enhanced NSC sphere formation and neurogenic fate commitment through activation of a Wnt signaling pathway and promoted NSC differentiation but did not affect proliferation of neuroblastoma cells.