Indole Alkaloids with New Skeleton Activating Neural Stem Cells
datasetposted on 07.11.2014 by Xing-Wei Yang, Cui-Ping Yang, Li-Ping Jiang, Xu-Jie Qin, Ya-Ping Liu, Qiu-Shuo Shen, Yong-Bin Chen, Xiao-Dong Luo
Datasets usually provide raw data for analysis. This raw data often comes in spreadsheet form, but can be any collection of data, on which analysis can be performed.
Alstoscholarisines A–E (1–5), five unprecedented monoterpenoid indole alkaloids with 6/5/6/6/6 fused-bridge rings, were isolated from Alstonia scholaris. They promoted adult neuronal stem cells (NSCs) proliferation significantly, in which the most active one (1) functioned from a concentration of 0.1 μg/mL in a dosage-dependent manner. Furthermore, 1 enhanced NSC sphere formation and neurogenic fate commitment through activation of a Wnt signaling pathway and promoted NSC differentiation but did not affect proliferation of neuroblastoma cells.