Immune related metagene clusters in TCGA and CGGA databases.

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posted on 2024-10-25, 17:29 authored by Feng Yuan, Yingshuai Wang, Lei Yuan, Lei Ye, Yangchun Hu, Hongwei Cheng, Yan Li

Immune related metagene clusters in TCGA and CGGA databases.

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tnf signaling pathway mitotic nuclear division important factors hindering central nervous system represent different tmes immunosuppressive tumor microenvironment immune cell distribution enrichment analysis revealed xlink "> firstly myeloid dendritic cells immune tolerance subtype highly reliable model four different subtypes different immune subtypes based new classification stemness maintenance phenotypes mainly closely related xlink "> glioma gliomas xlink ">stemness maintenance immune microenvironment classification model closely related four subtypes different stages mainly enriched immune therapy immune infiltration highest enrichment neuronal phenotypes mesenchymal subtype mesenchymal phenotypes immunogenic subtype highly heterogeneous highly correlated closely associated use david tumorigenic cytokines tcga database study aims strongly associated providing guidance nk cells neuronal phenotype monocytic lineage mesenchymal phenotype machine learning lowest proportion limited efficacy leukocyte activation idh mutation highest proportion highest expressed defined gliomas cytotoxic lymphocytes comprehensively analyzed clinical features cgga database 702 gliomas 693 gliomas 19q13 co

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