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High-performance wireless powering for peripheral nerve neuromodulation systems

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posted on 2017-10-24, 18:07 authored by Yuji Tanabe, John S. Ho, Jiayin Liu, Song-Yan Liao, Zhe Zhen, Stephanie Hsu, Chika Shuto, Zi-Yi Zhu, Andrew Ma, Christopher Vassos, Peter Chen, Hung Fat Tse, Ada S. Y. Poon

Neuromodulation of peripheral nerves with bioelectronic devices is a promising approach for treating a wide range of disorders. Wireless powering could enable long-term operation of these devices, but achieving high performance for miniaturized and deeply placed devices remains a technological challenge. We report the miniaturized integration of a wireless powering system in soft neuromodulation device (15 mm length, 2.7 mm diameter) and demonstrate high performance (about 10%) during in vivo wireless stimulation of the vagus nerve in a porcine animal model. The increased performance is enabled by the generation of a focused and circularly polarized field that enhances efficiency and provides immunity to polarization misalignment. These performance characteristics establish the clinical potential of wireless powering for emerging therapies based on neuromodulation.