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H93R_Pathogenic

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posted on 2023-06-11, 05:36 authored by siddharth sinha

A total of 213 PTEN missense variants comprising of 147 VUS, 54 ClinVar Pathogenic and 12 Benign variants were slected for classification utilizing the MD simulations study. 

Funding

This study was supported by grants from the Macau Science and Technology Development Fund (085/2017/A2, 0077/2019/AMJ, 0032/2022/A1), the University of Macau (SRG2017-00097-FHS, MYRG2019-00018-FHS, MYRG2020-00094-FHS), the Faculty of Health Sciences, University of Macau (FHSIG/SW/0007/2020P, MOE Frontiers Science Center for Precision Oncology pilot grant, and a startup fund) (SMW).

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    Keywords

    Computational Structure-Based Drug DesignMolecular Dynamics Simulation ApproachInCancer genomics screensGATK best-practicePTEN mutationsMD simulationREMDlipid phosphatase

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    CC BY 4.0

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