Fragment-based similarity scoring of the HY-L067 compound library.
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posted on 2025-04-10, 17:31 authored by Kerry McGowen, Tobias Funck, Xin Wang, Samuel Zinga, Ian D. Wolf, Chidiebere Akusobi, Claudia M. Denkinger, Eric J. Rubin, Mark R. SullivanFragment-based similarity scoring of the HY-L067 compound library.
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using mass spectrometryinadequate uptake impactsmeasured antibiotic accumulationexhibits intrinsic resistancepromote membrane permeabilitymembrane permeability contributewhether antibiotics failmycobacterium abscessus intrinsic antibiotic resistancefound multiple transporterscause linezolid resistancemembrane permeabilityantibiotic resistanceabscessus spectrum resistancelinezolid accumulateseffluxes linezolidwide rangeuncharacterized proteinpulmonary pathogenmechanisms requiredincompletely understoodidentify genesfactors drivingcritical mechanisms
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