Experimental design in five different groups of rats including control, silymarin and plant extracts of D. malabarica and G. odorata.
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posted on 2022-03-21, 17:37 authored by Arabinda Ghosh, Pranjal Sarmah, Harun Patel, Nobendu Mukerjee, Rajbardhan Mishra, Saad Alkahtani, Rajender S. Varma, Debabrat BaishyaExperimental design in five different groups of rats including control, silymarin and plant extracts of D. malabarica and G. odorata.
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nonlinear molecular dynamicsmolecular dynamics simulationmajor signaling proteinshplc analysis revealedgene expression profileeventually cause damagediv >< pcytochrome p450 enzymescritical physiological functionsaugmenting bilirubin content89 &# 17753 &# 17748 &# 177gynocardia odorata diospyros malabarica silico molecular dockingrevealed high bindinginduced hepatic injuryliver performs numberliver function analysiscauses liver damagequercetin (&# 916hepatotoxic wistar ratscytochrome p450 cyp2e1silico wistar ratsinduced hepatotoxicityhigh affinityliver leadssubstantial rolestudy highlightssignificant rolesgpt activitypotent inhibitorpossible mechanismplausible affinitymmp2 expressedmmgbsa studiesmechanistic rolehuman systemfruit extractsfree radicalscarbon tetrachloridebetter stability78 kcal
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