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Experimental design in five different groups of rats including control, silymarin and plant extracts of <i>D</i>. <i>malabarica</i> and <i>G</i>. <i>odorata</i>.

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posted on 2022-03-21, 17:37 authored by Arabinda Ghosh, Pranjal Sarmah, Harun Patel, Nobendu Mukerjee, Rajbardhan Mishra, Saad Alkahtani, Rajender S. Varma, Debabrat Baishya
<p>Experimental design in five different groups of rats including control, silymarin and plant extracts of <i>D</i>. <i>malabarica</i> and <i>G</i>. <i>odorata</i>.</p>

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    nonlinear molecular dynamicsmolecular dynamics simulationmajor signaling proteinshplc analysis revealedgene expression profileeventually cause damagediv >< pcytochrome p450 enzymescritical physiological functionsaugmenting bilirubin content89 &# 17753 &# 17748 &# 177gynocardia odorata </diospyros malabarica </silico molecular dockingrevealed high bindinginduced hepatic injuryliver performs numberliver function analysiscauses liver damagequercetin (&# 916hepatotoxic wistar ratscytochrome p450 cyp2e1silico </wistar ratsinduced hepatotoxicityhigh affinityliver leadssubstantial rolestudy highlightssignificant rolesgpt activitypotent inhibitorpossible mechanismplausible affinitymmp2 expressedmmgbsa studiesmechanistic rolehuman systemfruit extractsfree radicalscarbon tetrachloridebetter stability78 kcal

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