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Ethical losses responders computations.

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posted on 11.10.2021, 17:41 authored by Jean-Pierre Boissel, David Pérol, Hervé Décousus, Ingrid Klingmann, Marc Hommel

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Using numerical modeling and simulation to assess the ethical burden in clinical trials and how it relates to the proportion of responders in a trial sample
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using numerical modelingstatistical power increaseswell ), althoughreduce ethical lossesrcts emerged midtrial &# 8217treatment &# 8217rct &# 8217ethical loss reachesidentify trial participantsexperimental treatment bearrcts would contributercts progressively increasingunnecessary participants carryunnecessary participantsrcts ),ethical lossexperimental treatmentethical groundsexperimental armcontrolled trialxlink ">two armssquare comparingreal placeborct methodologyproportions observedprecise definitionnew therapieslast centuryinformative participantsinformation requiredgold standardevent whetherevent ratesethically acceptablecontrol armclinical trials100 %.

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