pone.0258093.s001.xlsx (96.77 kB)
Download fileEthical losses responders computations.
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posted on 2021-10-11, 17:41 authored by Jean-Pierre Boissel, David Pérol, Hervé Décousus, Ingrid Klingmann, Marc Hommel(XLSX)
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using numerical modelingstatistical power increaseswell ), althoughreduce ethical lossesrcts emerged midtrial &# 8217treatment &# 8217rct &# 8217ethical loss reachesidentify trial participantsexperimental treatment bearrcts would contributercts progressively increasingunnecessary participants carryunnecessary participantsrcts ),ethical lossexperimental treatmentethical groundsexperimental armcontrolled trialxlink ">two armssquare comparingreal placeborct methodologyproportions observedprecise definitionnew therapieslast centuryinformative participantsinformation requiredgold standardevent whetherevent ratesethically acceptablecontrol armclinical trials100 %.
