figshareBrowse
pone.0258093.s001.xlsx (96.77 kB)
Download file

Ethical losses responders computations.

Download (96.77 kB)
dataset
posted on 11.10.2021, 17:41 by Jean-Pierre Boissel, David Pérol, Hervé Décousus, Ingrid Klingmann, Marc Hommel

(XLSX)

History

Usage metrics

Read the peer-reviewed publication

Using numerical modeling and simulation to assess the ethical burden in clinical trials and how it relates to the proportion of responders in a trial sample
PLOS ONEPLOS ONE

Categories

Keywords

using numerical modelingstatistical power increaseswell ), althoughreduce ethical lossesrcts emerged midtrial &# 8217treatment &# 8217rct &# 8217ethical loss reachesidentify trial participantsexperimental treatment bearrcts would contributercts progressively increasingunnecessary participants carryunnecessary participantsrcts ),ethical lossexperimental treatmentethical groundsexperimental armcontrolled trialxlink ">two armssquare comparingreal placeborct methodologyproportions observedprecise definitionnew therapieslast centuryinformative participantsinformation requiredgold standardevent whetherevent ratesethically acceptablecontrol armclinical trials100 %.

Licence

CC BY 4.0

Exports