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Effect sizes for 200+ polygenic scores

Version 2 2021-11-30, 17:18
Version 1 2021-02-22, 18:12
dataset
posted on 2021-11-30, 17:18 authored by Florian PrivéFlorian Privé
- PGS-effects.csv.gz: vectors of effect sizes for 215 polygenic scores (PGS)
- pred-cor: partial correlations of these PGS with the corresponding phenotypes, in eight ancestry groups from the UK Biobank
- phenotype-description.xlsx: description of all phenotypes used in the study (30 were discarded due to very low prediction)
-> these report the best prediction from penalized regression and LDpred2.

We also provide these files separately for penalized regression (PLR) and LDpred2-auto (without using the test set).
The effect size file for penalized regression is very small because vectors of effects are very sparse.

Those are based on the UK Biobank data only.

Funding

Danish National Research Foundation (Niels Bohr Professorship to Prof. John McGrath)

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