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Donor specific transcriptomic analysis of Alzheimer's disease associated hypometabolism highlights a unique donor, microglia, and ribosomal proteins

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posted on 10.11.2020, 23:14 by Leon FrenchLeon French
Supplement data and figures from "Donor specific transcriptomic analysis of Alzheimer's disease associated hypometabolism highlights a unique donor, microglia, and ribosomal proteins"

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Extended Data Figure 1-1: Details of the FDG-PET studies used in the meta-analysis.

Extended Data Table 1-1: Complete GO enrichment results for all donors separately.

Extended Data Figure 3-1: Complete GO enrichment results for step-wise increases across DAM clusters.

Extended Data Figure 3-2: Complete GO enrichment results for step-wise increases across the human AD pathology subgroups.

Extended Data Figure 3-3: ER translocation gene step-wise results for other cell-types across the human AD pathology subgroups.

Supplement Figure 1: Differential expression of ER translocation genes in microglia from individuals with Alzheimer’s disease. In the top row, ROC curves show the proportion of ER translocation genes (y-axis, true positive fraction) across the genes tested for differential expression in microglia. The tested genes were ranked from the most overexpressed in early-pathology compared to no-pathology (A) and overexpressed in late-pathology compared to early-pathology (B). Subpanels C and D show the corresponding distributions with a black lines marking ER translocation genes across the differential expression rankings.

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