Donor specific transcriptomic analysis of Alzheimer's disease associated hypometabolism highlights a unique donor, microglia, and ribosomal proteins

Version 2 2020-11-10, 23:14

Version 1 2020-05-01, 21:01

dataset

posted on 2020-11-10, 23:14 authored by Leon FrenchLeon French

Supplement data and figures from "Donor specific transcriptomic analysis of Alzheimer's disease associated hypometabolism highlights a unique donor, microglia, and ribosomal proteins"

Preprint:

https://www.biorxiv.org/content/10.1101/2019.12.23.887364v4

Github:

https://github.com/leonfrench/AD-Allen-FDG

Extended Data Figure 1-1: Details of the FDG-PET studies used in the meta-analysis.

Extended Data Table 1-1: Complete GO enrichment results for all donors separately.

Extended Data Figure 3-1: Complete GO enrichment results for step-wise increases across DAM clusters.

Extended Data Figure 3-2: Complete GO enrichment results for step-wise increases across the human AD pathology subgroups.

Extended Data Figure 3-3: ER translocation gene step-wise results for other cell-types across the human AD pathology subgroups.

Supplement Figure 1: Differential expression of ER translocation genes in microglia from individuals with Alzheimer’s disease. In the top row, ROC curves show the proportion of ER translocation genes (y-axis, true positive fraction) across the genes tested for differential expression in microglia. The tested genes were ranked from the most overexpressed in early-pathology compared to no-pathology (A) and overexpressed in late-pathology compared to early-pathology (B). Subpanels C and D show the corresponding distributions with a black lines marking ER translocation genes across the differential expression rankings.