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Description of gene modules identified by WGCNA and the relationship of genes in modules to TNFa.

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posted on 2020-03-31, 17:31 authored by Brooke Rhead, Xiaorong Shao, Hong Quach, Poonam Ghai, Lisa F. Barcellos, Anne M. Bowcock

Description of gene modules identified by WGCNA and the relationship of genes in modules to TNFa.

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Global expression and CpG methylation analysis of primary endothelial cells before and after TNFa stimulation reveals gene modules enriched in inflammatory and infectious diseases and associated DMRs
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5BWeighted gene co-expression network analysisTNIP7RELOVL136 Disease Ontology termsexpression correlation patternsunderstanding disease etiologyHLA-CNFKBIAmoduleTNFAIP223 hypomethylated regionsHDACDDXARIDACLYDMRs Endothelial cellsCpG methylation analysisILSCDTNFa treatmentFASNchemokines CXCL 115 gene groupsTRAFdisease GWAS locitumor necrosis factor-alphaDNA methylation changesAPOCprecision medicine approaches

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