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Dataset from: "Plasticity in voltage-gated ion channels following overwintering in respiratory motoneurons of American bullfrogs"

dataset
posted on 2025-03-17, 15:33 authored by Renato FilogonioRenato Filogonio, Sandy E. Saunders, Michael Gray, José A. Viteri, Joseph M. Santin

For a full description of the methods, please check the original paper.

Below, please find a description of the files' content.


Files on firing rates: Hypoglossal_firing rate, Fast vagus_firing rate, Slow vagus_firing rate

Treatment: control and overwintered frogs

Current: input current (in picoamperes: pA) utilized during current clamp experiments to elicit neuronal firing rates

Firing rate: neuron firing rate (in hertz: Hz) elicited by each input current used



Files on membrane properties: Hypoglossal_membrane properties, Fast vagus_membrane properties, Slow vagus_membrane properties

Treatment: control and overwintered frogs

Resting potential: membrane resting potential (in millivolts: mV)

Input resistance: membrane input resistance (in mega Ohm: MΩ)



Files on latency and rheobase: Hypoglossal_latency and rheobase, Fast vagus_latency and rheobase, Slow vagus_latency and rheobase

Treatment: control and overwintered frogs

Latency: latency for first spike (in milli seconds: ms) after current stimulation

Rheobase: minimum current (in pico amperes: pA) necessary to elicit a spike in the measured neuron



Files on Calcium currents: Hypoglossal_Ca currents, Fast vagus_Ca currents, Slow vagus_Ca currents

Treatment: control and overwintered frogs

Voltage: voltage (in millivolts: mV) used in voltage clamp experiments eliciting measured currents

Peak current: current (in pico amperes normalized by capacitance: pA/pF) measured at the peak response

Steady state current: current (in pico amperes normalized by capacitance: pA/pF) measured after the current reached a steady state



Files on Potassium currents: Hypoglossal_K currents, Fast vagus_K currents, Slow vagus_K currents

Treatment: control and overwintered frogs

Voltage: voltage (in millivolts: mV) used in voltage clamp experiments eliciting measured currents

Total current: total potassium current (in pico amperes normalized by capacitance: pA/pF) measured

High threshold current: high threshold potassium current (in pico amperes normalized by capacitance: pA/pF) measured

A-current: potassium A-current (in pico amperes normalized by capacitance: pA/pF), calculated by subtracting high threshold currents from total current



Files on sodium persistent inward currents (NaPIC): Hypoglossal_Na persistent inward currents, Fast vagus_Na persistent inward currents, Slow vagus_Na persistent inward currents

Treatment: control and overwintered frogs

Holding current: in pico amperes normalized by capacitance (pA/pF)

Current amplitude: difference between the holding current and the peak response (in pico amperes normalized by capacitance: pA/pF)

Peak voltage: voltage (in milli volts: mV) where the current peak response was identified

Voltage sensitivity: the slope (in pico amperes over milli volts: pA/mV) of the change in current (in pico amperes: pA) by the change in voltage (in milli volts: mV)

Funding

National Institutes of Health (R01NS114514)

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