Cytotoxicity of Naps on THP-1 cells.
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posted on 2025-02-05, 18:37 authored by Katy Poncin, Samantha A. McKeand, Hayley Lavender, Kacper Kurzyp, Odile B. Harrison, Annabell Roberti, Charlotte Melia, Errin Johnson, Martin C. J. Maiden, David R. Greaves, Rachel Exley, Christoph M. TangResults of LDH release (measured by the OD490 of assays on cell supernatants) from THP-1 cells in the presence of individual mNaps. Lysis buffer shows the LDH release from 100% of cells.
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programmed cell deathdetectable antimicrobial activityaltruistic death provides2 invasive speciesimportant human pathogensneisseria gonorrhoeae ><nap island contributedlike peptides encodedp neisseria nap u ><like peptidesn eisseria strains lackingstationary phasespecific pathogenphase variableobvious benefitmultiple roleslife cycleleading causelargely restrictedinvasive diseaseinflammatory conditionhuman cellsgenitourinary tractgenes presentevolutionary conundrumclosely relatedcelled organismsbacterial meningitis
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