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Cobalt-Catalyzed Thiolative Lactonization of Alkynes with Double CO Incorporation

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posted on 2011-09-12, 00:00 authored by Yoshihiro Higuchi, Shingo Atobe, Michiru Tanaka, Ikuyo Kamiya, Takuya Yamamoto, Akihiro Nomoto, Motohiro Sonoda, Akiya Ogawa
When the Co2(CO)8-catalyzed reaction of alkynes with thiols is conducted under the pressure of carbon monoxide, a novel thiolative lactonization with simultaneous introduction of two carbon monoxide molecules into the carbon–carbon triple bonds takes place successfully to afford α,β-unsaturated γ-thio-γ-lactones with excellent regioselectivity.