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posted on 2016-05-16, 01:19 authored by Yoshito HaradaYoshito Harada
 Encoded spatial expression patterns of 73 C. intestinalis regulatory genes in the 110-cell stage and AND logical conjunction results of them.
 The order of binary digits is A7-1, A7-2, A7-5, A7-6, A8-5, A8-6, A8-7, A8-8, A8-13, A8-14, A8-15, A8-16, a8-17, a8-19, B7-1, B7-2, B7-5, B7-6, B7-7, B8-5, B8-6, B8-7, B8-8, B8-15, B8-16, b8-17, b8-19, and b8-27. The blue diagonal represents the expression of 73 regulatory genes. Other cells display logical conjunction results of regulatory gene expression.
 The color of each cell: beige, pink, yellow, green, aqua blue, pale blue, purple, and gray genes represent transcription factors (bHLH transcription factors for the first beige rows), zinc finger proteins, proteins involved in the Notch pathway, proteins involved in the Wnt pathway, proteins involved in the TGF-b pathway (except Tolloid (BMP-1) metalloprotease), proteins involved in the Eph/ephrin pathway, proteins involved in the FGF pathway, and other regulatory genes, respectively. Although I temporarily categorized all zinc finger proteins into the “DNA/RNA-binding protein” class in this table, their biochemical properties must be examined by individual “wet bench” works.

 Please see the details in the paper:

Trends Dev Biol. 9, 29-42 (2016)
Reverse engineering of animal development
Yoshito Harada


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