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ppat.1010312.s020.xlsx (10.98 kB)
Chromatin state at chromosome 10q24.
dataset
posted on 2022-09-19, 17:42 authored by James J. Gilchrist, Kathryn Auckland, Tom Parks, Alexander J. Mentzer, Lily Goldblatt, Vivek Naranbhai, Gavin Band, Kirk A. Rockett, Ousmane B. Toure, Salimata Konate, Sibiri Sissoko, Abdoulaye A. Djimdé, Mahamadou A. Thera, Ogobara K. Doumbo, Samba Sow, Sian Floyd, Jörg M. Pönnighaus, David K. Warndorff, Amelia C. Crampin, Paul E. M. Fine, Benjamin P. Fairfax, Adrian V. S. HillChromatin state segmentation data (http://genome.ucsc.edu/cgi-bin/hgFileUi?db=hg19&g=wgEncodeBroadHmm) across 9 cell types (H1 ES, embryonic stem cells; K562, erythrocytic leukemia cells; GM12878, B-lymphoblastoid cells; HepG2, hepatocellular carcinoma cells; HUVEC, umbilical vein endothelial cells; HSMM, skeletal muscle myoblasts; NHLF, normal lung fibroblasts, NHEK, normal epidermal keratinocytes; HMEC, mammary epithelial cells) at 33 99%credible set SNPs for the leprosy association at chromosome 10q24.
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wide association studysup >&# 8722selection pressure drivenrecent positive selectionperipheral nerves causedone population mayinfectious disability globallydespite recent improvementscharacterise regulatory activity81 × 1030 susceptibility lociinflammatory bowel diseaseestablished risk locidisease insights deriveddiv >< pmycobacterium leprae shared genetic architecturelocus shows evidence40 − 0mali genetic architecturedisease controlatopic diseasep leprosy riskslc29a3 lacc1 actr1a using publiclyuncertain whethersignificant burdenpreviously describedonset asthmamodern populationsmhc classindian populationsimportant causedemonstrates pleiotropydata highlightsci 0chronic infectioncandidate mediatoravailable dataafrican populations64 ]).436 controls368 controls327 cases247 cases
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