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Chiral Diene as the Ligand for the Synthesis of Axially Chiral Compounds via Palladium-Catalyzed Suzuki−Miyaura Coupling Reaction

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posted on 03.12.2010, 00:00 by Shu-Sheng Zhang, Zhi-Qian Wang, Ming-Hua Xu, Guo-Qiang Lin
The first palladium−diene-catalyzed asymmetric Suzuki−Miyaura coupling reaction has been achieved. A number of functionalized biaryls were obtained in high yields and in moderate to high enantioselectivities. The existence of an ortho-formyl group greatly improves the catalyst efficiency and permits further synthetic elaborations.