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Catalyst-Free Regioselective C‑3 Thiocyanation of Imidazopyridines

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posted on 2015-11-06, 00:00 authored by Daoshan Yang, Kelu Yan, Wei Wei, Guoqing Li, Shenglei Lu, Caixia Zhao, Laijin Tian, Hua Wang
A direct and straightforward approach for highly regioselective thiocyanation of imidazoheterocycles through sp2 C–H functionalization has been realized at room temperature. Various C-3 thiocyanated imidazopyridines are formed in moderate to good yield. The present method exhibits a mild and selective access to a variety of imidazopyridine derivatives of pharmacological interest.