Cancer Dependency Map, CRISPR Avana dataset 18Q2 (Avana_public_18Q2)
datasetposted on 18.06.2018 by Broad Institute Cancer Dependency Map, Cancer Data Science
Datasets usually provide raw data for analysis. This raw data often comes in spreadsheet form, but can be any collection of data, on which analysis can be performed.
Avana_public_18Q2 contains the results of screening 436 cancer cell lines with the Avana CRISPR-Cas9 genome-scale knockout library generated as part of the Broad Institute's Cancer Dependency Map project.
As our screening efforts continue, we will be releasing additional cancer dependency data on a quarterly basis for unrestricted use. For the latest datasets available, further analyses, and to subscribe to our mailing list visit https://depmap.org.
Descriptions of the experimental methods and the CERES algorithm are published in http://dx.doi.org/10.1038/ng.3984. Some cell lines were processed using copy number data based on the Sanger Institute whole exome sequencing data (COSMIC: http://cancer.sanger.ac.uk/cell_lines, EGA accession number: EGAD00001001039) reprocessed using CCLE pipelines.
Avana_public_18Q2 includes the results of 46 lines not previously made public, while the previously published line HS294T has been dropped for fingerprinting failure.