Biomimetic Models of the Active Site of the Metalloenzyme Nitrile Hydratase

posted on 02.09.2012 by Dirk Schweitzer

In the interest of a wider dissemination of the knowledge contained therein, the author's PhD Thesis, entitled "Biomimetic Models of the Active Site of the Metalloenzyme Nitrile Hydratase" (University of Washington, Seattle, 2001), is reproduced here. To illustrate the evolution of knowledge, the author's Precandidacy (1998) and General Exam (1999) papers and a poster (2000) are included.

All of the experimental results contained within this PhD thesis have by now been reported in journal articles. However, this thesis provided room for a much more detailed presentation of the experimental results and their discussion and analysis.

{FeNO}6 model compound [chapter 2]: Journal of the American Chemical Society 1998, 120, 10996-10997 http://pubs.acs.org/doi/abs/10.1021/ja981117e

Oxygenated Co(III)-thiolate complexes [pages 16-17 & 113-116]: Journal of the American Chemical Society 2000122, 8299-8300  http://pubs.acs.org/doi/abs/10.1021/ja0017561

Improved synthesis of tetramethylammonium azide: Croatica Chemica Acta 200174, 415-418 http://public.carnet.hr/ccacaa/CCA-PDF/cca2001/v74-n2/cca_74_2001_415-418_Schweitzer.pdf

Reactivity as a function of an Et,Pr or Pr,Pr ligand backbone to model the entatic state of an enzymatic active site [chapter 3]: Inorganic Chemistry 2002, 41, 3128-3136 http://pubs.acs.org/doi/abs/10.1021/ic0109187

Fe(III) complexes of an (Namide)2(Sthiolate)2 ligand [chapter 4]: Inorganic Chemistry 2008, 47, 11228-11236 http://pubs.acs.org/doi/abs/10.1021/ic801704n