An analytical approach of doxofylline: review
Doxofylline is chemically designated as 7-(1, 3 dioxolone-2-yl methyl) theophylline. Presence of a dioxolane group in
position C-7 differentiates it from theophylline. It is a new antibronchospastic drug recently introduced in therapy with
pharmacological properties like theophylline; a potent adenosine receptor antagonist. doxofylline do not affect gastric acid secretion; either invivo or in-vitro; unlike theophylline. The lack of side effects with doxofylline indicates that the drug can be used safely and effectively. Some analytical methods for quantitative determination of doxofylline in pharmaceutical formulations like UV-Spectrophotometry, HPLC and LC-MS are reported. The present review deals with the various analytical methods reported as well as adopted for the estimation of doxofylline.
CONCLUSION:
Doxofylline is available and frequently used in market;
hence, there is great need to determine it in bulk, dosage
form as well as to estabilish pharmacokinetic parameters.
The need of analytical method validation is well reflect and
highlights the aspect of analyst’s personal habits, that from
part of the developed methods, and on the possibility of a
person getting very reproducible results when he carries out
the analysis again and again in a similar set of conditions.
Any developed method however, may be influenced by
variable like different elapsed assay times, different days,
reagent lots, instruments, equipments or apparatus,
environmental condition like temperature etc.
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Keywords
DoxofyllineAsian Journal of Pharmaceutical Analysisantibronchospastic drugUV-SpectrophotometryHPLC and LC-MSclinical research of doxofylineAnalytical BiochemistryAnalytical Chemistry not elsewhere classifiedAnalytical SpectrometryAllergyBasic PharmacologyChemotherapyClinical and Sports NutritionClinical Chemistry (diagnostics)Clinical MicrobiologyClinical Nursing: Primary (Preventative)Clinical Nursing: Secondary (Acute Care)Clinical Nursing: Tertiary (Rehabilitative)Clinical Pharmacology and TherapeuticsClinical Pharmacy and Pharmacy PracticeClinical Sciences not elsewhere classifiedCommunity Child HealthEmergency MedicineEnvironmental and Occupational Health and SafetyEpidemiologyFamily CareHealth and Community ServicesHealth CareHealth Care AdministrationHealth CounsellingHealth Information Systems (incl. Surveillance)Health PromotionHuman BiophysicsHuman Movement and Sports Science not elsewhere classifiedIntensive CareMedical and Health Sciences not elsewhere classifiedMedical BacteriologyMedical Biochemistry and Metabolomics not elsewhere classifiedMedical Infection Agents (incl. Prions)Pacific Peoples HealthPaediatricsPathogenesisPharmaceutical SciencesPharmacogenomicsPharmacology and Pharmaceutical Sciences not elsewhere classifiedPreventive MedicinePrimary Health CareRespiratory DiseasesToxicology (incl. Clinical Toxicology)Traditional Chinese Medicine and Treatments
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