ol5003576_si_005.cif (1.86 MB)
Download file

Aminodiols via Stereocontrolled Oxidation of Methyleneaziridines

Download (1.86 MB)
posted on 17.12.2015, 01:11 by Jared W. Rigoli, Ilia A. Guzei, Jennifer M. Schomaker
A highly diastereoselective Ru-catalyzed oxidation/reduction sequence of bicyclic methyleneaziridines provides a facile route to complex 1-amino-2,3-diol motifs. The relative anti stereochemistry between the amine and the vicinal alcohol are proposed to result from 1,3-bischelation in the transition state by the C1 and C3 heteroatoms.