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Additional file 2 of Cord blood DNA methylome in newborns later diagnosed with autism spectrum disorder reflects early dysregulation of neurodevelopmental and X-linked genes

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posted on 15.10.2020 by Charles E. Mordaunt, Julia M. Jianu, Benjamin I. Laufer, Yihui Zhu, Hyeyeon Hwang, Keith W. Dunaway, Kelly M. Bakulski, Jason I. Feinberg, Heather E. Volk, Kristen Lyall, Lisa A. Croen, Craig J. Newschaffer, Sally Ozonoff, Irva Hertz-Picciotto, M. Daniele Fallin, Rebecca J. Schmidt, Janine M. LaSalle
Additional file 2: Table S1. Subject characteristics in relation to outcome at 36 months. Table S2. Subject characteristics table by subject. Table S3. Associations between ASD diagnosis, global CpG methylation, and the proportion of nRBCs. Table S4. ASD DMRs identified in discovery males with annotation and covariate association. Table S5. ASD DMRs identified in discovery females with annotation and covariate association. Table S6. ASD DMRs identified in males are maintained with adjustment for nRBC proportion. Table S7. ASD DMR methylation is associated with diagnosis after adjustment for all cord blood cell types. Table S8. ASD DMRs adjusting for sex identified in all discovery subjects with annotation and covariate association. Table S9. ASD DMRs identified in replication males with annotation and covariate association. Table S10. ASD DMRs identified in replication females with annotation and covariate association. Table S11. ASD DMRs adjusting for sex identified in all replication subjects with annotation and covariate association. Table S12. ASD DMRs replicate by region overlap with an independent computational method. Table S13. DMR methylation assayed by WGBS correlates with DMR methylation assayed by bisulfite pyrosequencing. Table S14. ASD DMRs replicate by region overlap with an independent sample set. Table S15. ASD DMRs replicated by region overlap with an independent sample set. Table S16. ASD DMRs replicated by differential methylation in an independent sample set. Table S17. ASD DMRs associated with autism severity among ASD subjects in multiple sample sets. Table S18. Replicated DMR and DMB genes with annotation. Table S19. ASD DMRs replicate by gene overlap with conservative mapping. Table S20. ASD DMBs identified in discovery males with annotation. Table S21. ASD DMBs identified in discovery females with annotation. Table S22. ASD DMBs identified in replication males with annotation. Table S23. ASD DMBs identified in replication females with annotation. Table S24. ASD DMB genes replicate in independent sample sets and overlap with DMR genes.

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National Institute of Environmental Health Sciences National Institute of Child Health and Human Development Environmental Protection Agency (US) Autism Speaks Canadian Institutes of Health

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