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A Cu(II) complex: treatment activity on intracerebral hemorrhage via inhibiting inflammatory response in vascular endothelial cells

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posted on 2020-08-24, 09:46 authored by Jing Liu, Hong-Wei Zhao, Yong-Pan Tian, Yu Yang, Ji-Xiang Wu

A new Cu(II)-based coordination polymer (CP), {[Cu(bpa)(1,3-BDC)(H2O)](DMF)n}n (1), (DMF = dimethylformamide) was synthesized by reaction of the Cu(NO3)2·3H2O with the 3,6-bis(benzimidazol-1-yl)pyridazine (bpa) presence of the isophthalic acid (1,3-H2BDC). Its intracerebral hemorrhage (ICH) protective treatment was assessed and the related mechanism was explored as well. The real time RT-PCR was used to detect the relative expression levels of the ROS related genes, which reflected the intracellular ROS levels in the vascular endothelial cells. Next, the western blotting assay was performed and the inflammatory responses levels in the vascular endothelial cells were evaluated.