16S rRNA sequencing data of fecal samples from three breeds of boars at time points before, during and after the use of amoxicillin. A total of 103 stud boars of 3 breeds were used as experimental animals in this study, including 40 large white (LW), 47 landrace (LAN) and 16 duroc (DUR) stud boars. The starting time of the experiment was defined as Day 0 (D0). Amoxicillin was added to the diet at a dose of 100 mg/kg feed and started on day 3 (D3), with all other conditions remaining the same. The administration of amoxicillin was stopped on the seventh day (D7) of the experiment and the normal diet was used until the 14th day (D14). Fresh fecal samples were collected on days 0, 7 and 14, frozen in liquid nitrogen