GraphRepur.zip (41.09 MB)
GraphRepur: Breast Cancer Drug Repurposing
softwareposted on 2021-03-16, 01:54 authored by ChenChen
A graph neural network model GraphRepur based on GraphSAGE for drug repurposing against breast cancer. GraphRepur integrated two major classes of computational methods, drug network-based and drug signature-based. The differentially expressed genes of disease, drug-exposure gene expression data, and the drug-drug links information were collected. By extracting the drug signatures and topological structure information contained in the drug relationships, GraphRepur can predict new drugs for breast cancer.