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Three new phenylspirodrimane derivatives with inhibitory effect towards potassium channel Kv1.3 from the fungus Stachybotrys chartarum

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posted on 2019-07-25, 12:23 authored by Jia-Min Feng, Min Li, Jin-Lian Zhao, Xiao-Na Jia, Ji-Mei Liu, Min Zhang, Ri-Dao Chen, Ke-Bo Xie, Da-Wei Chen, Hai-Bo Yu, Jun-Gui Dai

Three new phenylspirodrimanes derivatives named stachybotrysins H and I (1 and 2) and stachybotrin E (3), together with one known compound stachybotrylactam (4), were isolated from Stachybotrys chartarum CGMCC 3.5365. Their structures were determined by extensive NMR data and mass spectroscopic analysis. Compounds 1 and 2 showed inhibitory effect towards potassium channel Kv1.3 with IC50 values of 13.4 and 10.9 μM, respectively.

Funding

This work was financially supported by CAMS Innovation Fund for Medical Sciences (nos. CIFMS-2016-I2M-3-012 and CIFMS-2016-I2M-2-002), the National Science Foundation of China (no. 81803403), and Beijing Key laboratory of Non-Clinical Drug Metabolism and PK/PD Study (no. Z141102004414062).

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    Journal of Asian Natural Products Research

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    Phenylspirodrimanes derivativesStachybotrys chartarumpotassium channel Kv1.3

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    CC BY 4.0

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