<i>pgrn-1(-)</i> resistance to ER stress may be partially dependent on the UPR pathway, <i>daf-16</i> and <i>pmk-1</i>.

<p>(A) Embryos from the indicated strains were grown on plates with tunicamycin (TM) and assessed for their ability to develop to the L4 stage. (B) <i>daf-2(e1370)</i> and <i>daf-16(mu86)</i> were tested for ER stress resistance with and without <i>pgrn-1(-)</i> in the background. (C) <i>daf-16(mu86); muIs113</i> and <i>pgrn-1(tm985); muIs113</i> animals were tested for ER stress resistance. (D) <i>pmk-1(km25)</i> and <i>pgrn-1(-); pmk-1(-)</i> mutants were tested for ER stress resistance. Error bars represent standard deviation. Statistical comparisons are to N2 control (Two-way ANOVA with Bonferroni post-tests). *p<0.05, **p<0.01, ***p<0.001. For additional statistical data, see <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003714#pgen.1003714.s016" target="_blank">Table S4A</a>–D.</p>

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