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miR-34a induces cell cycle arrest and inhibits tumorigenesis in proneural GBM cells.

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posted on 2012-03-27, 00:54 authored by Joachim Silber, Anders Jacobsen, Tatsuya Ozawa, Girish Harinath, Alicia Pedraza, Chris Sander, Eric C. Holland, Jason T. Huse

A) 48 hours post-transfection, proneural TS543 were pulsed with BrdU and assayed for cell cycle distribution and B) apoptosis by Annexin V flow cytometry. Staurosporine was added as positive control. C) Ex vivo-transfected TS453 cells stably expressing a luciferase reporter plasmid were xenografted into the brains of ICR scid mice and tumor formation and growth was followed over 11 days. Error bars represent standard deviation within a single experimental set containing multiple replicates. Similar results were obtained in at least 3 independent experiments. *, P<0.05. **, P<0.005.

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