Figure_1.tif (459.95 kB)
mRNA expression of drug transporters in HNSCC.
figure
posted on 2014-10-02, 03:54 authored by Rolf Warta, Dirk Theile, Carolin Mogler, Esther Herpel, Niels Grabe, Bernd Lahrmann, Peter K. Plinkert, Christel Herold-Mende, Johanna Weiss, Gerhard Dyckhoff(A) Determination of mRNA expression levels of drug transporters by qRT-PCR in a study sample of therapy naïve stage IVa HNSCC tumors (n = 40, grey boxes) and normal control samples (n = 14, white boxes) (relative mRNA expression normalized to the lowest value). (B) External validation by HNSCC RNAseq mRNA expression data derived from the ‘The Cancer Genome Atlas’ (TCGA) consortium. Comparison of normalized counts of paired tumor (n = 37, grey boxes) and adjacent noncancerous normal tissue (n = 37, white boxes). Whisker indicates 5–95 percentile; Mann-Whitney U test; **, p<0.01; ***, p<0.001.
History
Usage metrics
Categories
Keywords
drug efflux transportersABCG 2Stage IV HeadCancer Genome Atlas databasesurvivalmrpïve stage IV headoscopper transporter ATP 7b mRNA expressiontranscription polymerase chain reactionbcrpAnalyzing mRNA expression levels31ANeck Squamous Cell Carcinoma Drug transportersabcctmadrug transportersDrug Transporter ExpressionHigh ABCB 1 mRNA tumor expressionhnsccslcProtein expressionpfs
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC