mRNA expression of drug transporters in HNSCC.
(A) Determination of mRNA expression levels of drug transporters by qRT-PCR in a study sample of therapy naïve stage IVa HNSCC tumors (n = 40, grey boxes) and normal control samples (n = 14, white boxes) (relative mRNA expression normalized to the lowest value). (B) External validation by HNSCC RNAseq mRNA expression data derived from the ‘The Cancer Genome Atlas’ (TCGA) consortium. Comparison of normalized counts of paired tumor (n = 37, grey boxes) and adjacent noncancerous normal tissue (n = 37, white boxes). Whisker indicates 5–95 percentile; Mann-Whitney U test; **, p<0.01; ***, p<0.001.