mDC gain the capacity to secrete IFN-α upon virus stimulation following SIV infection.

<p>(A) Dot plots showing intracellular IFN-α expression in blood mDC from untreated and DV056-treated macaques at day 0 and day 14 post infection after iSIV stimulation. Data for all animals are shown, along with a representative dot plot of cells exposed to control microvesicles. Flow cytometric gating to define mDC was done as in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1003530#ppat-1003530-g001" target="_blank">Figure 1</a>. (B) Percent of blood mDC producing IFN-α after iSIV stimulation at the indicated times after infection in untreated and DV056-treated macaques. *<i>P</i><.05, **<i>P</i><.01.</p>