<i>tert</i>-Buyldiphenylsilylethyl (“TBDPSE”): A Practical Protecting Group for Phenols
2005-02-18T00:00:00Z (GMT) by
A new protection group for phenols, the 2-(<i>tert</i>-butyldiphenylsilyl)ethyl (TBDPSE) group, has been prepared and investigated. Protection of a variety of substituted phenols proceeds in good to excellent yield. The group is stable to mild acid, base, hydrogenolysis conditions, and lithium/halogen exchange on the protected phenol. Removal is achieved with strong acid or standard fluoride treatment.
CC BY-NC 4.0