Schizocalyx cuspidatus (A. St.-Hil.) Kainul. & B. Bremer extract improves antioxidant defenses and accelerates the regression of hepatic fibrosis after exposure to carbon tetrachloride in rats

Vilela Gonçalves, Reggiani; Dias Novaes, Rômulo; Matias Sarandy, Mariáurea; Paulo Viana Leite, João; Ferreira Vilela, Emerson; do Carmo Cupertino, Marli; Luis Pinto da Matta, Sérgio

doi:10.6084/m9.figshare.2302069.v1

gnpl_a_1143825_sm3576.pdf (182.08 kB)

Schizocalyx cuspidatus (A. St.-Hil.) Kainul. & B. Bremer extract improves antioxidant defenses and accelerates the regression of hepatic fibrosis after exposure to carbon tetrachloride in rats

journal contribution

posted on 2016-02-17, 18:10 authored by Reggiani Vilela Gonçalves, Rômulo Dias Novaes, Mariáurea Matias Sarandy, João Paulo Viana Leite, Emerson Ferreira Vilela, Marli do Carmo Cupertino, Sérgio Luis Pinto da Matta

The aim of this study was to investigate the effect of leaves extract of Schizocalyx cuspidatus (A. St.-Hil.) Kainul. & B. Bremer on hepatic morphofunctional dysfunction induced by carbon tetrachloride (CCl₄). Liver lesions were induced via intraperitoneal administration of CCl₄ every 48 h for 12 days. Forty-nine rats were randomised into seven groups: G1: CCl₄; G2: CCl₄ (animals euthanised 24 h after last CCl₄ application); G3: CCl₄ + DMSO; G4: SCE 400 mg/kg; G5: DMSO (700 μl); G6: CCl₄ + SCE 200 mg/kg and G7: CCl₄ + SCE 400 mg/kg. SCE administration resulted in reduction in hydroperoxide levels, lipidic droplets and necrosis compared to G1, G2 and G3. There was an increase in the amount of collagen fibres in G1, G2 and G3 compared to the groups. These results show that the extract of SCE leaves has great potential for the recovery of liver damage after the application of CCl₄.